Understanding GLP-1 Injections: How They Work and Who Can Benefit by Dr. Platamone
What Are GLP-1 Injections?
GLP-1 injections are medications designed to mimic a natural hormone called glucagon-like peptide-1 (GLP-1) that your body produces when you eat. This hormone plays an important role in regulating blood sugar, controlling hunger, and slowing down digestion.
Originally developed for managing Type 2 diabetes, these injections have shown significant benefits for people with obesity and other metabolic conditions, offering a new treatment option for those who need help with weight loss and blood sugar control.
How Do GLP-1 Injections Work?
GLP-1 injections work in several key ways:
Blood sugar regulation: They help the pancreas release insulin when blood sugar levels rise, keeping glucose levels steady.
Slower digestion: The injections slow down the rate at which food leaves the stomach, helping to prolong feelings of fullness.
Appetite suppression: These medications act on the brain to reduce hunger and cravings.
As a result, GLP-1 injections can help people eat less and manage their blood sugar levels more effectively.
Who Can Benefit from GLP-1 Injections?
We generally prescribe these medications for people who:
Have Type 2 diabetes and need better control of their blood sugar levels.
Struggle with obesity or being overweight, especially if they have health conditions like high blood pressure or high cholesterol.
Are at high risk of heart disease because GLP-1 medications can also offer cardiovascular protection.
However, these medications are not suitable for everyone. People with certain conditions, such as a history of pancreatitis or certain types of thyroid cancer, should avoid them.
How Much Weight Can You Lose with GLP-1 Injections?
In clinical studies, GLP-1 injections have led to significant weight loss in many patients. On average, people can expect to lose between 10% and 20% of their body weight over the course of a year, depending on the specific medication and individual factors.
For example, Wegovy (semaglutide) has shown an average weight loss of about 15% for people with obesity. Other medications like Mounjaro (tirzepatide) have shown even higher results, with some patients losing up to 20% or more of their body weight.
While this weight loss is promising, it’s important to note that some of it may come from muscle mass rather than just fat. This is especially a concern with medications that suppress appetite and slow digestion. Preserving muscle mass is key to maintaining long-term health and preventing frailty.
To protect your muscle mass while using these medications, lifting weights and engaging in resistance training are highly recommended. This will help keep your muscles strong, prevent weight regain once the medication is stopped, and reduce the risk of developing frailty in the future.
Side Effects of GLP-1 Injections
Like all medications, GLP-1 injections come with potential side effects. The most common ones include:
Nausea (especially when starting the medication)
Stomach discomfort (like bloating, gas, or constipation)
Feeling full quickly, which can affect appetite
In some cases, people may also experience gastrointestinal issues like diarrhea or constipation. While side effects often improve as the body adjusts to the medication, they can be uncomfortable for some.
There are also rare but more serious side effects, including pancreatitis (inflammation of the pancreas) and gallbladder problems. These are not common but are important to be aware of.
Other Benefits and Risks
In addition to helping with weight loss and diabetes, GLP-1 medications may also have other potential benefits, such as:
Cardiovascular protection: They may reduce the risk of heart attacks and strokes, particularly in people with diabetes.
Kidney protection: Some studies suggest that GLP-1 medications can help protect the kidneys, especially for people with diabetes.
However, GLP-1 medications are not without risks. Muscle loss can happen if exercise is not part of the weight loss plan. Some people may experience gastrointestinal side effects, like nausea and vomiting. Rarely, there may be more serious side effects, such as pancreatitis or problems with the gallbladder. These are not common but should be monitored by your healthcare provider.
How to Get GLP-1 Injections and Who Should Consider Them
GLP-1 injections are available by prescription, so if you’re considering them, a discussion with your doctor is essential. Having a primary care physician who knows your whole health history leads to appropriate treatment and monitoring. Beware of med spas and other services which only do prescription drug weight loss.
It’s also worth noting that insurance coverage for these medications can vary. Some insurance plans cover them for diabetes management, but weight loss treatments may require additional approval or come with higher out-of-pocket costs.
Final Thoughts
GLP-1 injections have revolutionized the management of diabetes and weight loss, offering a promising option for those struggling with metabolic health. However, like any medication, they work best when part of a comprehensive, physician-guided plan tailored to your unique health needs.
That’s why having a primary care physician who truly knows you is crucial. At EuDoc, our direct primary care model ensures you receive personalized, ongoing medical supervision—not just a prescription. We take the time to understand your full health picture, monitor potential risks, and help you achieve sustainable, long-term results.
If you're considering GLP-1 therapy, don’t settle for one-size-fits-all care. Join EuDoc today and experience healthcare that puts you first.
